Friday
Organizers:
Stephen Bryant
National Institutes of Health
[email protected]
Teresa Przytycka
National Institutes of Health
[email protected]
Presented under the auspices of the Special Focus on Computational
Molecular Biology.
Protein domains may be defined as elementary units of protein
structure and evolution, capable, to some extent, of folding and
functioning autonomously. Understanding of domain structure, function
and evolution is a fundamental step towards understanding of a living
organism. Identification of protein domains provides an inside into
protein function.
Current databases provide a vast amount of protein sequence and
structure data, and it is likely that members of the majority of
protein families have been already observed. Thus we are in the
position to ask a question which could not be addressed previously:
Can one use this information to identify domain sequences and
structures computationally? How can we extract their properties?
By analyzing the database of known sequences and structures and the
properties of conserved domains we hope to get some insight into
domain identification, properties and evolution. The amount of the
data, it's complexity and biological context open challenges of an
interdisciplinary nature. For example, identification of a structural
domain requires on one hand sophisticated algorithms that can search
for patterns in 3-dimensional data and on the other hand a clear,
biologically meaningful and computationally tractable, definition of
protein domain.
The workshop is devoted to computational challenges in this new phase
of understanding protein domain organization. The goal of the workshop
is be to bring together biological and computational/mathematical
scientists to discuss the state of art and the open questions focusing
on the following aspects of protein domains:
Methods for identification of protein domains.
Protein domain comparison and classification.
Mechanisms of domain evolution.
Topological and geometrical properties of protein domains.
Relation between sequence and structure conservation.
Leading specialists of the field will give invited
presentations. There will be a poster session and we invite poster
contributions.
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Registration fees:
(Pre-registration deadline: February 20, 2003)
Regular rate
Preregister before deadline $120/day
After preregistration deadline $140/day
Reduced Rate*
Preregister before deadline $60/day
After preregistration deadline $70/day
Postdocs
Preregister before deadline $10/day
After preregistration deadline $15/day
DIMACS Postdocs $0
Non-Local Graduate & Undergraduate students
Preregister before deadline $5/day
After preregistration deadline $10/day
Local Graduate & Undergraduate students $0